(PDF) Association of a Newly Identified Variant of DNA

The E295K DNA . polymerase beta gastric cancer-associated variant interferes . with base excision repair and induces cellular transformation. Mol Cell Biol, 27, 5587-96. (PDF) Association of a Newly Identified Variant of DNA The E295K DNA . polymerase beta gastric cancer-associated variant interferes . with base excision repair and induces cellular transformation. Mol Cell Biol, 27, 5587-96.

(PDF) Cellular Roles of DNA Polymerase Beta

merase beta found in human gastric cancer-- The E295K DNA p olymerase. Mammalian DNA polymerase-beta is the smallest known eukaryotic polymerase and Cancer-Associated DNA Polymerase Beta VariantsCancer-Associated DNA Polymerase Beta Variants Joann B. Sweasy, Ph.D. Departments of Therapeutic Gastric 40 20 (50) Colorectal 8 6 (75) Prostate 12 2 (17) Lung 11 3 (27) Breast 42 11 (26) E295K result in cellular transformation. Cancer-Associated DNA Polymerase Beta VariantsCancer-Associated DNA Polymerase Beta Variants Joann B. Sweasy, Ph.D. Departments of Therapeutic Gastric 40 20 (50) Colorectal 8 6 (75) Prostate 12 2 (17) Lung 11 3 (27) Breast 42 11 (26) E295K result in cellular transformation.

Crystal Structure of DNA Polymerase with DNA

The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation Lang, Tieming; Dalal, Shibani; Chikova, Anna; DiMaio, Daniel; Sweasy, Joann B. DNA polymerase beta promoter mutations affect gene Lang T, Dalal S, Chikova A et al (2007) The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Mol Cell Biol 27(15):55875596. PubMed; Article; CAS; Google Scholar Human DNA polymerase polymorphism, Arg137Gln, The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation,

Inhibition of poly(ADP-ribose) polymerase down-regulates

(2007) The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Mol Cell Biol 27:5587 5596. Involvement of DNA polymerase beta overeion in the Jul 05, 2013 · This mutant pol along with the others, i.e. pol E295K, K289M and I260M mutants identified in gastric cancer, colon cancer and prostate cancer can compete with wild-type pol to interfere base lesion repair conferring a dominant-negative effect on BER leading to cellular malignant transformation phenotypes such as loss of anchorage Leu22Pro tumor-associated variant of DNA polymerase beta Nov 26, 2007 · The gastric cancer-associated E295K variant is polymerase deficient and acts in a dominant negative manner to interfere with BER. This variant also induces sister chromatid exchanges in mouse cells ( 16 ).

Polbase - Authors

Loop II of DNA polymerase beta is important for polymerization activity and fidelity. Sweasy JB 2007 Nucleic acids research The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Sweasy JB 2007 RCSB PDB - 4R64:Binary complex crystal structure of E295K Structures of binary and ternary substrate complexes of the R258A mutant and a mutant associated with gastric carcinomas, E295K, provide molecular insight into intermediate structural conformations not appreciated previously. Tieming Lang - Method Development Scientist - Bayer Crop The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Mol Cell Biol. August 27, 2007

Unfavorable Electrostatic and Steric Interactions in DNA

Mutations in DNA polymerase (pol ) have been associated with approximately 30% of human tumors. The E295K mutation of pol has been linked to gastric carcinoma via interference with base excision repair. To interpret the different behavior of E295K as compared to wild-type pol in atomic and energetic detail, we resolve a binary crystal complex of E295K at 2.5 Å and apply transition Unfavorable electrostatic and steric interactions in DNA Mutations in DNA polymerase (pol ) have been associated with approximately 30% of human tumors. The E295K mutation of pol has been linked to gastric carcinoma via interference with base excision repair. To interpret the different behavior of E295K as compared to wild-type pol in atomic and en The E295K DNA polymerase beta gastric cancer-associated The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. [Tieming Lang, Shibani Dalal, Anna Chikova, Daniel DiMaio, Joann B Sweasy]